Rabbit Anti-Akt Antibody MBS628872 from MyBioSource.com

Description

Akt is also referred to as PKB or Rac. It plays a critical role in controlling the balance between survival and apoptosis (1-3). This protein kinase is activated by insulin and various growth and survival factors. it functions in a wortmannin-sensitive pathway involving PI3 kinase (2,3). Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 (4). It is also activated by phosphorylation within the C-terminus at Ser473. Akt functions to promote cell survival by inhibiting apoptosis by means of its ability to phosphorylate and inactivate several targets, including Bad (5), Forkhead transcription factors (6) and caspase-9. PTEN phosphatase is a major negative regulator of the PI3 kinase/Akt signaling pathway (7). LY294002 is a specific PI3 kinase inhibitor (8)

Product Specs
ItemRabbit Anti-Akt Antibody
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS628872
Quantity0.1 mL
ApplicationsWestern Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Conjugate/TagUnconjugated
FormatSupplied as liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. No preservative added
PurityAffinity Purified
Purified by Protein A and peptide affinity chromatography
ReactivityHuman, Mouse, Rat
TargetAkt
IsotypeIgG
Molecular Weight68,485 Da
HostRabbit
ImmunogenDetects endogenous levels of Akt only when phosphorylated at Thr308. Does not detect Akt phosphorylated at other sites or related kinases such as PKC and p70 S6 kinase. Species Crossreactivity: Human, mouse, rat and hamster. Expected to crossreact with chicken and Xenopus based on sequence homology
NCBI Gene Aliasesdakt1, dAKT/dPKB, PKB/dAKT, AKT/PKB, AKT, AKT1, dakt, D-Akt, DAKT1, DPKB, dAKT1, Dmel\CG4006, p-Akt, DAKT1/PKB, PKB, dAkt, DRAC-PK66, pAkt, dAKT, Dpkb, P-AKT, PKB/Akt, DAkt1, DRAC-PK, Akt/PKB, Akt, Akt1, DAKT, dAkt1, CG4006, l(3)04226, DRAC-PK85, RAC, dPKB, Dakt1, RacPK, dAkt/PKB, akt, akt1, Dakt, PKB/AKT, l(3)89Bq, DAkt
ClonalityPolyclonal